Saturation transfer difference NMR reveals functionally essential kinetic differences for a sugar-binding repressor protein

Literature Information

Publication Date 2009-08-19
DOI 10.1039/B913489A
Impact Factor 6.222
Authors

Ignacio Pérez-Victoria, Sebastian Kemper, Mitul K. Patel, John M. Edwards, James C. Errey, Lucia F. Primavesi, Matthew J. Paul, Timothy D. W. Claridge, Benjamin G. Davis


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Abstract

The binding kinetics of disaccharides trehalose and trehalose-6-phosphate to repressor protein TreR have been determined using STD NMR and shed light on the contrasting biological roles of these two sugars.

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