Facile synthesis of stapled, structurally reinforced peptide helices via a photoinduced intramolecular 1,3-dipolar cycloaddition reaction
Literature Information
Michael M. Madden, Claudia I. Rivera Vera, Wenjiao Song, Qing Lin
We report the first use of a photoinduced 1,3-dipolar cycloaddition reaction in “stapling” peptide sidechains to reinforce a model peptide helical structure with moderate to excellent yields; the resulting pyrazoline “staplers” exhibit unique fluorescence useful in a cell permeability study.
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