Copper-catalyzed enantioselectivecarbenoidinsertion into S–H bonds‡

Literature Information

Publication Date 2009-08-11
DOI 10.1039/B911670B
Impact Factor 6.222
Authors

Yong-Zhen Zhang, Shou-Fei Zhu, Yan Cai, Hong-Xiang Mao, Qi-Lin Zhou


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Abstract

An asymmetriccarbenoidinsertion into S–H bonds catalyzed by copper–chiral spiro bisoxazoline complexes has been developed, in which a series of α-mercaptoesters were produced in high yields with moderate to good enantioselectivities (up to 85% ee); this result represents the best enantioselectivity in the catalytic asymmetriccarbenoid S–H bond insertion reaction.

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