A new route to 3-acyl-2-aminobenzofurans: palladium-catalysed cycloisomerisation of 2-(cyanomethyl)phenyl esters

Literature Information

Publication Date 2009-05-07
DOI 10.1039/B904127C
Impact Factor 6.222
Authors

Masahito Murai, Koji Miki, Kouichi Ohe


View Original

Abstract

Treatment of 2-(cyanomethyl)phenyl esters with a catalytic amount of Pd(OAc)2, PCy3, and Zn afforded 3-acyl-2-aminobenzofuran derivatives in good to excellent yields, which can be used as building blocks for the synthesis of benzofuran fused heterocycles.

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