Greatly reduced amino acid alphabets in directed evolution: making the right choice for saturation mutagenesis at homologous enzyme positions

Literature Information

Publication Date 2008-10-02
DOI 10.1039/B813388C
Impact Factor 6.222
Authors

Manfred T. Reetz, Sheng Wu


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Abstract

Enantioselective mutants of the thermally robust phenyl acetone monooxygenase (PAMO) as catalysts in Baeyer–Villiger reactions have been evolved by utilizing saturation mutagenesis in which drastically reduced amino acid alphabets are employed at homologous enzyme positions.

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