Cymantreneconjugation modulates the intracellular distribution and induces high cytotoxicity of a cell-penetrating peptide‡
Literature Information
Ines Neundorf, Jan Hoyer, Katrin Splith, Robert Rennert, Harmel W. Peindy N’Dongo, Ulrich Schatzschneider
The conjugation of cymantreneCpMn(CO)3 to cell-penetrating peptide hCT(18-32)-k7 alters the intracellular distribution in MCF-7 cells compared to the unmodified peptide, as visualized by fluorescence microscopy, and leads to an increased nuclear accumulation; the peptide and cymantrene compound themselves are not toxic, but the bioconjugate shows a significant cytotoxicity with an IC50 value of 36 μmol l−1.
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