Probing lipase/esterase libraries for lipid A hydrolases—discovery of biocatalysts for the detoxification of bacterially-expressed recombinant protein

Literature Information

Publication Date 2004-01-19
DOI 10.1039/B312662E
Impact Factor 6.222
Authors

Jung-Mo Ahn, Paul Wentworth, Jr., Kim D. Janda


View Original

Abstract

In our ongoing efforts to develop new methods for lipopolysaccharide (LPS) detoxification, we have screened lipase/esterase libraries for the ability to deacylate the 2′- and 3′-fatty acid chains from lipid A: the most active esterases were successfully employed to inactivate LPSs in a crude concentrated cell supernatant of E. Coli containing a recombinant single chain antibody (scFv).

Related Literature

Acetyl protected thiol methacrylic polymers as effective ligands to keep quantum dots in luminescent standby mode

Marta Liras, Isabel Quijada-Garrido, Marta Palacios-Cuesta, Sonia Muñoz-Durieux, Olga García

2013-08-30 Paper

DOI: 10.1039/C3PY00987D

Back cover

Cover

DOI: 10.1039/C3PY90086J

Glutathione-triggered disassembly of isothermally responsive polymer nanoparticles obtained by nanoprecipitation of hydrophilic polymers

Daniel J. Phillips, Joseph P. Patterson, Rachel K. O'Reilly, Matthew I. Gibson

2013-08-15 Paper

DOI: 10.1039/C3PY00991B

Back cover

Cover

DOI: 10.1039/C3PY90089D

Combining oxyanionic polymerization and click-chemistry: a general strategy for the synthesis of polyether polyol macromonomers

Anja Thomas, Kerstin Niederer, Frederik Wurm, Holger Frey

2013-09-26 Paper

DOI: 10.1039/C3PY01078C

A novel route for polymerisation of thiophene based conducting polymers using trace-free oxidants

Jimy Hadiono So, David Mayevsky, Orawan Winther-Jensen, Bjorn Winther-Jensen

2013-10-10 Communication

DOI: 10.1039/C3PY01265D

Polymer patchy colloids with sticky patches

Yi Zhao, Rüdiger Berger, Katharina Landfester, Daniel Crespy

2013-09-12 Paper

DOI: 10.1039/C3PY01096A

Poly(methacrylic acid) complexation of amphotericin B to treat neglected diseases

Ji-won Choi, Denis Martin, Vanessa Yardley, Keith Powell, Antony Godwin

2013-10-08 Paper

DOI: 10.1039/C3PY01051A

Copper-mediated living radical polymerization (SET-LRP) of lipophilic monomers from multi-functional initiators: reducing star–star coupling at high molecular weights and high monomer conversions

Christopher Waldron, Athina Anastasaki, Ronan McHale, Paul Wilson, Zaidong Li, Tim Smith, David M. Haddleton

2013-10-01 Paper

DOI: 10.1039/C3PY01241G

Manganese(iii) acetylacetonate initiated RAFT polymerizations: an alternative and versatile RAFT initiator

Zhigui Zheng, Yuan Zhou, Zhengbiao Zhang, Xiulin Zhu

2013-07-31 Communication

DOI: 10.1039/C3PY00879G

You might also like

Compound Q&A

What are the main uses of 1H-Indazole-6-carbonitrile (CAS: 141290-59-7)?

1H-Indazole-6-carbonitrile finds applications in pharmaceuticals, where it serve...

141290-59-71H-Indazole-6-carbon...
Compound Q&A

How should waste containing Dioctyl (2E)-2-butenedioate (CAS: 2997-85-5) be handled?

Waste containing Dioctyl (2E)-2-butenedioate (CAS: 2997-85-5) should be collecte...

2997-85-5Dioctyl (2E)-2-buten...
Compound Q&A

What industries use Sodium [(1,2-benzoxazol-3-ylmethyl)sulfonyl]azanide (CAS: 68291-98-5)?

Sodium [(1,2-benzoxazol-3-ylmethyl)sulfonyl]azanide is primarily used in pharmac...

68291-98-5Sodium [(1,2-benzoxa...
Compound Q&A

Are there alternatives to Dimethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,6-pyridinedicarboxylate (CAS: 741709-66-0) in synthesis?

Dimethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,6-pyridinedicarboxyla...

741709-66-0Dimethyl 4-(4,4,5,5-...
Compound Q&A

How should waste containing 2-Fluoro-6-hydrazinopyridine (CAS: 80714-39-2) be handled?

Waste containing 2-Fluoro-6-hydrazinopyridine (CAS: 80714-39-2) should be manage...

80714-39-22-Fluoro-6-hydrazino...
Compound Q&A

What is 6-Formyl-2-pyridinecarboxylic acid (CAS: 499214-11-8)?

6-Formyl-2-pyridinecarboxylic acid is an organic compound with the molecular for...

499214-11-86-Formyl-2-pyridinec...
900874-91-13-(3,4-dimethoxyphen...
Compound Q&A

How is 9H-Tribenzo[b,d,f]azepine (CAS: 29875-73-8) typically synthesized?

9H-Tribenzo[b,d,f]azepine is typically synthesized via a multi-step process invo...

29875-73-89H-Tribenzo[b,d,f]az...
Compound Q&A

How is 1-Cyclopropyl-7-ethoxy-6-fluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid (CAS: 1797982-51-4) typically synthesized?

1-Cyclopropyl-7-ethoxy-6-fluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinolinecarboxyli...

1797982-51-41-Cyclopropyl-7-etho...
Compound Q&A

How should waste containing Methyl 3-oxo-1,2,3,4-tetrahydro-6-quinoxalinecarboxylate (CAS: 671820-52-3) be handled?

Waste containing Methyl 3-oxo-1,2,3,4-tetrahydro-6-quinoxalinecarboxylate (CAS: ...

671820-52-3Methyl 3-oxo-1,2,3,4...

Source Journal

Chemical Communications

Chemical Communications
CiteScore: 8.6
Self-citation Rate: 4.7%
Articles per Year: 2458

ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry

Recommended Compounds

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.