Internal amide-triggered cycloaromatization of maduropeptin-like nine-membered enediyne

Literature Information

Publication Date 2008-09-15
DOI 10.1039/B811355F
Impact Factor 6.222
Authors

Yutaro Norizuki, Kazuo Komano, Itaru Sato, Masahiro Hirama


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Abstract

In the Masamune–Bergman cyclization of a nine-membered non-conjugated enediyne with an internal, maduropeptin-like nucleophile, the exocyclic alkene migrated to form the nine-membered conjugated enediyne, triggered by the intramolecular addition of the amide group; final aromatized products showed up to 85% yield.

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