Enantioselective regulation of a metal complex in reversible binding to serum albumin: dynamic helicity inversion signalled by circularly polarised luminescence
Literature Information
Craig P. Montgomery, Elizabeth J. New, David Parker, Robert D. Peacock
The helicity of the (SSS)-Δ enantiomer of a terbium and europium(III) complex is inverted on reversible binding to ‘drug site II’ of serum albumin, signalled by a switch in its circularly polarised emission; no such behaviour occurs with the (RRR)-Λ complexes, thereby defining a unique chiroptical probe of albumin binding.
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![2,6-Di(thiophen-2-yl)dithieno[3,2-b:2',3'-d]thiophene structure 2,6-Di(thiophen-2-yl)dithieno[3,2-b:2',3'-d]thiophene structure](https://static.chemtradehub.com/structs/910/910788-24-8-5b70.webp)

