Enantioselective regulation of a metal complex in reversible binding to serum albumin: dynamic helicity inversion signalled by circularly polarised luminescence

Literature Information

Publication Date 2008-09-10
DOI 10.1039/B810978H
Impact Factor 6.222
Authors

Craig P. Montgomery, Elizabeth J. New, David Parker, Robert D. Peacock


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Abstract

The helicity of the (SSS)-Δ enantiomer of a terbium and europium(III) complex is inverted on reversible binding to ‘drug site II’ of serum albumin, signalled by a switch in its circularly polarised emission; no such behaviour occurs with the (RRR)-Λ complexes, thereby defining a unique chiroptical probe of albumin binding.

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