Nickel-catalyzed cross-coupling reactions of benzylic zinc reagents with aromatic bromides, chlorides and tosylates

Literature Information

Publication Date 2008-04-24
DOI 10.1039/B803072C
Impact Factor 6.222
Authors

Matthias A. Schade, Albrecht Metzger, Stephan Hug, Paul Knochel


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Abstract

Benzylic zinc reagents prepared by direct insertion of zinc to benzylic chlorides in the presence of LiCl undergo smooth cross-coupling reactions with aromatic chlorides, bromides and tosylates using Ni(acac)2 and PPh3 as a catalyst system.

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