A near-infrared fluorescent probe for lipid hydroperoxides in living cells
Literature Information
Publication Date
2008-05-15
DOI
10.1039/B802836B
Impact Factor
4.616
Authors
Ping Li, Bo Tang, Yanlong Xing, Puming Li, Guiwen Yang, Liang Zhang
View Original
Abstract
An NIR (near-infrared) fluorescent probe TCP (tricarbocyanine diphenylphosphine) including a non-conjugated ‘pre-tricarbocyanine’ was designed and synthesized for visualizing lipid hydroperoxides (ROOH) in living cells. The excitation and emission spectra of tricarbocyanine in the NIR region can effectively avoid background fluorescence interference in biological systems. The probe exhibited a rapid fluorescence response to ROOH and high selectivity for ROOH over other ROS (reactive oxygen species) and some biological compounds, and the limit of detection was 38 pM. In addition, the probe was stable, and less cytotoxic, which indicated that it has potential application in detecting lipid hydroperoxides in living biological systems.
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Source Journal
Analyst
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Recommended Compounds
![2-Hydroxy-4-[({[(4-methylphenyl)sulfonyl]oxy}acetyl)amino]benzoic acid structure](https://static.chemtradehub.com/structs/501/501919-59-1-579f.webp "2-Hydroxy-4-[({[(4-methylphenyl)sulfonyl]oxy}acetyl)amino]benzoic acid structure")
2-Hydroxy-4-[({[(4-methylphenyl)sulfonyl]oxy}acetyl)amino]benzoic acid
CAS Number:
501919-59-1
Molecular Formula:
C16H15NO7S
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