N-Metalated imines by reaction of 1,1-diethoxybut-2-ene with aromatic nitriles, as useful intermediates for the synthesis of substituted pyrimidines and cyclopentenones‡
Literature Information
Marco Blangetti, Annamaria Deagostino, Cristina Prandi, Paolo Venturello
A new approach to the synthesis of pyrimidines and cyclopentenones is described. The method exploits the reactivity of α,β-unsaturated acetals with aromatic nitriles in the presence of the Schlosser’s superbase LIC-KOR.
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amine structure [(2-chlorophenyl)methyl](ethyl)amine structure](https://static.chemtradehub.com/structs/629/62924-61-2-0728.webp)
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![Ethanone, 1-[4-chloro-2-(methylthio)-5-pyrimidinyl]- structure Ethanone, 1-[4-chloro-2-(methylthio)-5-pyrimidinyl]- structure](https://static.chemtradehub.com/structs/661/66116-82-3-863e.webp)