Crystal structure and silica condensing activities of silicatein α–cathepsin L chimeras‡

Literature Information

Publication Date 2008-02-11
DOI 10.1039/B718264C
Impact Factor 6.222
Authors

Michael Fairhead, Kenneth A. Johnson, Thomas Kowatz, Stephen A. McMahon, Lester G. Carter, Muse Oke, Huanting Liu, James H. Naismith, Christopher F. van der Walle


View Original

Abstract

Cathepsin L mutants with the ability to condense silica from solution have been generated and a 1.5 Å crystal structure of one of these chimeras allows us to rationalise the catalytic mechanism of silicic acid condensation.

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