![2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-(6-quinolinyl)acetamide structure](https://static.chemtradehub.com/structs/501/501921-61-5-756a.webp "2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-(6-quinolinyl)acetamide structure")
2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-(6-quinolinyl)acetamide
CAS Number:
501921-61-5
Molecular Formula:
C26H18ClN3O2
Maximizing the relaxivity of HSA-bound gadolinium complexes by simultaneous optimization of rotation and water exchange
Literature Information
Publication Date
2007-10-26
DOI
10.1039/B714438E
Impact Factor
6.222
Authors
Stefano Avedano, Lorenzo Tei, Alberto Lombardi, Giovanni B. Giovenzana, Silvio Aime, Dario Longo, Mauro Botta
View Original
Abstract
Two new GdEGTA (EGTA = ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid) derivatives incorporating aromatic moieties into the oxoethylenic bridge have been prepared and characterised, their conjugates to HSA investigated and an unprecedented high relaxivity, close to that predicted by theory, interpreted in terms of the combined effect of restricted local rotation and fast rate of water exchange.
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Source Journal
Chemical Communications
CiteScore:
8.6
Self-citation Rate:
4.7%
Articles per Year:
2458
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