An esterase-activated magnetic resonance contrast agent
Literature Information
Marco Giardiello, Mark P. Lowe, Mauro Botta
A Gd(III) complex bearing pendant acetoxymethyl esters is activated on exposure to porcine liver esterase; the 84% increase in relaxivity is a result of suppression of HCO3−/CO32− binding by the resulting negative charge.
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