An esterase-activated magnetic resonance contrast agent

Literature Information

Publication Date 2007-09-14
DOI 10.1039/B711989E
Impact Factor 6.222
Authors

Marco Giardiello, Mark P. Lowe, Mauro Botta


View Original

Abstract

A Gd(III) complex bearing pendant acetoxymethyl esters is activated on exposure to porcine liver esterase; the 84% increase in relaxivity is a result of suppression of HCO3−/CO32− binding by the resulting negative charge.

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