Catalytic asymmetric hydrogenation of aldehydes

Literature Information

Publication Date 2007-04-05
DOI 10.1039/B703977H
Impact Factor 6.222
Authors

Xiaoguang Li, Benjamin List


View Original

Abstract

Racemic α-arylaldehydes provide the corresponding primary alcoholsvia dynamic kinetic resolution in excellent enantioselectivities and yields upon hydrogenation using a Noyori ruthenium catalyst; for example, the biologically active (S)-enantiomer of the non-steroidal anti-inflammatory drug ibuprofen could be synthesized via catalytic enantioselective hydrogenation of aldehyde1f followed by oxidation with potassium permanganate in 76% isolated yield and 96 : 4 er.

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Contents list

Front/Back Matter

DOI: 10.1039/C2AN90127G

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