Catalytic asymmetric hydrogenation of aldehydes
Literature Information
Xiaoguang Li, Benjamin List
Racemic α-arylaldehydes provide the corresponding primary alcoholsvia dynamic kinetic resolution in excellent enantioselectivities and yields upon hydrogenation using a Noyori ruthenium catalyst; for example, the biologically active (S)-enantiomer of the non-steroidal anti-inflammatory drug ibuprofen could be synthesized via catalytic enantioselective hydrogenation of aldehyde1f followed by oxidation with potassium permanganate in 76% isolated yield and 96 : 4 er.
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![Bis[(1,2,3,4,5-eta)-1-(diphenylphosphino)cyclopentadienyl]iron structure Bis[(1,2,3,4,5-eta)-1-(diphenylphosphino)cyclopentadienyl]iron structure](https://static.chemtradehub.com/structs/121/12150-46-8-ecd2.webp)
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