Viral MRI contrast agents: coordination of Gd by native virions and attachment of Gd complexes by azide–alkyne cycloaddition

Literature Information

Publication Date 2007-01-15
DOI 10.1039/B615084E
Impact Factor 6.222
Authors

Duane E. Prasuhn, Jr., Robert M. Yeh, Andre Obenaus, Marianne Manchester, M. G. Finn


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Abstract

Icosahedral virus particles decorated with a Gd(DOTA) analogue by Cu-mediated azide–alkyne cycloaddition (CuAAC) and/or with Gd3+ ions by coordination to the viral nucleoprotein show increased T1 relaxivity relative to free Gd(DOTA) complexes in solution.

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