Viral MRI contrast agents: coordination of Gd by native virions and attachment of Gd complexes by azide–alkyne cycloaddition
Literature Information
Duane E. Prasuhn, Jr., Robert M. Yeh, Andre Obenaus, Marianne Manchester, M. G. Finn
Icosahedral virus particles decorated with a Gd(DOTA) analogue by Cu-mediated azide–alkyne cycloaddition (CuAAC) and/or with Gd3+ ions by coordination to the viral nucleoprotein show increased T1 relaxivity relative to free Gd(DOTA) complexes in solution.
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![N-[(6-Bromo-3-pyridinyl)methyl]ethanamine structure N-[(6-Bromo-3-pyridinyl)methyl]ethanamine structure](https://static.chemtradehub.com/structs/120/120740-05-8-ca55.webp)

![4,4-Difluoro-2-methyl-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline structure 4,4-Difluoro-2-methyl-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline structure](https://static.chemtradehub.com/structs/119/1194032-23-9-f426.webp)

