Enantioselective rhodium-catalyzed addition of arylboronic acids to trifluoromethyl ketones
Literature Information
Sébastien L. X. Martina, Richard B. C. Jagt, Johannes G. de Vries, Ben L. Feringa, Adriaan J. Minnaard
The catalytic asymmetric 1,2-addition of a series of arylboronic acids to 2,2,2-trifluoroacetophenones is described with high isolated yields (up to 96%) and good enantioselectivities (up to 83% ee) using a rhodium(I)/phosphoramidite catalyst.
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