Enantioselective rhodium-catalyzed addition of arylboronic acids to trifluoromethyl ketones

Literature Information

Publication Date 2006-08-22
DOI 10.1039/B609453H
Impact Factor 6.222
Authors

Sébastien L. X. Martina, Richard B. C. Jagt, Johannes G. de Vries, Ben L. Feringa, Adriaan J. Minnaard


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Abstract

The catalytic asymmetric 1,2-addition of a series of arylboronic acids to 2,2,2-trifluoroacetophenones is described with high isolated yields (up to 96%) and good enantioselectivities (up to 83% ee) using a rhodium(I)/phosphoramidite catalyst.

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