Biomimetic synthesis of marine sponge metabolite spiculoic acid A and establishment of the absolute configuration of the natural product

Literature Information

Publication Date 2006-06-12
DOI 10.1039/B607035C
Impact Factor 6.222
Authors

James E. D. Kirkham, Victor Lee, Jack E. Baldwin


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Abstract

The synthesis of spiculoic acid A (1) using a biomimetic Diels–Alder reaction is described; comparison of the specific rotation of the natural and synthetic material revealed that the enantiomer of the natural product has been synthesized.

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