l-Proline in an ionic liquid as an efficient and reusable catalyst for direct asymmetric α-aminoxylation of aldehydes and ketones
Literature Information
Lin-Feng Cun, Ai-Qiao Mi, Yao-Zhong Jiang, Jian-Ji Wang
Proline-catalyzed direct asymmetric α-aminoxylation of aldehydes and ketones in the room temperture ionic liuqid 1-n-butyl-3-methylimidazolium tetrafluoroborate achieved high yields and high enantioselectivities, even when just 1–5% of proline was used as the catalyst; immobilisation of the catalyst in an ionic liquid phase offers simple product isolation and the reuse of the catalytical system at least four times in subsequent reactions.
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![(2S)-2-({N-[(2S)-2-Ammonio-4-methylpentanoyl]glycyl}amino)-3-phenylpropanoate structure (2S)-2-({N-[(2S)-2-Ammonio-4-methylpentanoyl]glycyl}amino)-3-phenylpropanoate structure](https://static.chemtradehub.com/structs/429/4294-25-1-0842.webp)