Selective functionalization of imidazolesvia an iodine–copper exchange reaction

Literature Information

Publication Date 2006-04-20
DOI 10.1039/B603419E
Impact Factor 6.222
Authors

Xiaoyin Yang, Paul Knochel


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Abstract

The reaction of protected 4,5-diiodoimidazoles with (PhMe2CCH2)2CuLi regioselectively provides 5-cuprated imidazoles, which readily react with various electrophiles furnishing functionalized imidazoles in good yields; remarkably, these resulting mono-iodoimidazoles undergo again an iodine–copper exchange reaction in the presence of sensitive functional groups, like an aldehyde or a ketone.

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