Two novel non-viral gene delivery vectors: low molecular weight polyethylenimine cross-linked by (2-hydroxypropyl)-β-cyclodextrin or (2-hydroxypropyl)-γ-cyclodextrin

Literature Information

Publication Date 2006-03-22
DOI 10.1039/B601130F
Impact Factor 6.222
Authors

Hongliang Huang, Guping Tang, Qingqing Wang, Da Li, Fenping Shen, Jun Zhou, Hai Yu


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Abstract

Two novel polymers of low molecular weight polyethylenimine cross-linked by (2-hydroxypropyl)-β-cyclodextrin or (2-hydroxypropyl)-γ-cyclodextrin showed lower cytotoxicity and higher transfection efficiency for the delivery of plasmid DNA compared with those of polyethylenimine (PEI, 25 kDa).

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