Sterically-controlled regioselective para-substitutions of aniline

Literature Information

Publication Date 2005-06-24
DOI 10.1039/B506824J
Impact Factor 6.222
Authors

John Fawcett, Gerald A. Griffith, Céline Olivier, Adam R. Patterson, Samuel Suhard


View Original

Abstract

Introduction of sterically demanding 1-isopropyl-2-methylpropyl or triisopropylsilyl groups at the nitrogen of aniline allows high-yielding regioselective para-substitution to be achieved using a lithiation/substitution sequence.

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