Sterically-controlled regioselective para-substitutions of aniline
Literature Information
John Fawcett, Gerald A. Griffith, Céline Olivier, Adam R. Patterson, Samuel Suhard
Introduction of sterically demanding 1-isopropyl-2-methylpropyl or triisopropylsilyl groups at the nitrogen of aniline allows high-yielding regioselective para-substitution to be achieved using a lithiation/substitution sequence.
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