Annulation of benzaldehydes with norbornenes toward indanones assisted by monodentate transient directing groups via double C–H activation
Literature Information
Publication Date
2023-12-06
DOI
10.1039/D3QO01790G
Impact Factor
5.281
Authors
Jinyuan Wang, Yunzhi Liu, Nan Han, Yuan Gao, Jun Luo
View Original
Abstract
A novel synthetic strategy for indanones was established through a Pd-catalyzed direct annulation of benzaldehydes with norbornenes assisted by anilines as monodentate transient directing groups. The reaction proceeds smoothly under mild conditions and generates indanones with moderate to excellent yields. This protocol exhibits a broad functional group compatibility and high atom economy. Mechanistic investigations revealed that consecutive ortho aromatic C–H and carbonyl C–H activations of benzaldehydes are involved in the reaction.
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Organic Chemistry Frontiers
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