The enzymology of clavam and carbapenem biosynthesis

Literature Information

Publication Date 2005-08-08
DOI 10.1039/B505964J
Impact Factor 6.222
Authors

Nadia J. Kershaw, Matthew E. C. Caines, Mark C. Sleeman, Christopher J. Schofield


View Original

Abstract

The enzyme-catalysed reactions involved in formation of the bicyclic clavam and carbapenem nuclei, including β-amino acid and β-lactam formation, are discussed and compared with those involved in penicillin and cephalosporin biosynthesis. The common role of unusual oxidation reactions in the biosynthetic pathways and the lack of synthetic reagents available to effect them are highlighted.

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