Investigations of the waterclusters of the protected amino acid Ac-Phe-OMe by applying IR/UV double resonance spectroscopy: microsolvation of the backbone

Literature Information

Publication Date 2010-03-10
DOI 10.1039/C000424C
Impact Factor 3.676
Authors

Holger Fricke, Kirsten Schwing, Andreas Gerlach, Claus Unterberg, Markus Gerhards


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Abstract

In order to investigate the influence of hydration on the backbone of a peptide or protected amino acid, the successive aggregation of water to Ac-Phe-OMe is analysed by means of IR/UV double resonance spectroscopy. To achieve meaningful results the spectra have been recorded in the region of the amide A and OH stretching vibrations as well as the amide I/II modes. Comparison with ab initio and DFT calculations leads to size-selective structural assignments. Two isomers of the mono- and dihydrated clusters and one isomer of the trihydrated cluster are observed in the molecular beam leading to a formation of the first solvation shell of the backbone. In case of the trihydrated cluster the backbone geometry is remarkably changed compared to the structure of the monomer since a network of water molecules can be formed.

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Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
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