Superparamagnetic gadonanotubes are high-performance MRI contrast agents

Literature Information

Publication Date 2005-07-08
DOI 10.1039/B504435A
Impact Factor 6.222
Authors

Balaji Sitharaman, Kyle R. Kissell, Keith B. Hartman, Lesa A. Tran, Andrei Baikalov, Irene Rusakova, Yanyi Sun, Htet A. Khant, Steven J. Ludtke, Wah Chiu, Sabrina Laus, Éva Tóth, Lothar Helm, André E. Merbach, Lon J. Wilson


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Abstract

We report the nanoscale loading and confinement of aquated Gd3+n-ion clusters within ultra-short single-walled carbon nanotubes (US-tubes); these Gd3+n@US-tube species are linear superparamagnetic molecular magnets with Magnetic Resonance Imaging (MRI) efficacies 40 to 90 times larger than any Gd3+-based contrast agent (CA) in current clinical use.

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ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry

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