(2S)-2-(Fluoromethyl)piperidine hydrochloride (1:1)
CAS Number:
886216-73-5
Molecular Formula:
C6H13ClFN
Formal base-free homolytic aromatic substitutions via photoredox catalysis
Literature Information
Publication Date
2015-03-26
DOI
10.1039/C5QO00031A
Impact Factor
5.281
Authors
Filipe Gomes, Vanessa Narbonne, Florent Blanchard
View Original
Abstract
We developed a simple and convenient method to assemble biaryls exploiting a photoredox catalyst and visible light. Diazonium salts generate aryl radicals that could then add on unactivated (hetero)arenes and the sequence eventually delivers products via formal homolytic aromatic substitutions. The direct C–H arylation of these usually unreactive substrates is achieved at room temperature using low catalyst loadings and shows broad functional group tolerance.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
(S)-(9H-Fluoren-9-yl)methyl (pyrrolidin-2-ylmethyl)carbamate hydrochloride
CAS Number:
1217813-15-4
Molecular Formula:
C20H23ClN2O2
4-(Dimethylaminomethyl)phenylacetic acid hydrochloride
CAS Number:
99985-52-1
Molecular Formula:
C11H16ClNO2
1-(3-Fluorophenyl)-1H-1,2,4-triazole-3-carboxylic acid
CAS Number:
1292369-51-7
Molecular Formula:
C9H6FN3O2
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