A peptide-catalyzed asymmetric Stetter reaction

Literature Information

Publication Date 2004-11-29
DOI 10.1039/B414574G
Impact Factor 6.222
Authors

Steven M. Mennen, Jarred T. Blank, Michelle B. Tran-Dubé, Jason E. Imbriglio, Scott J. Miller


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Abstract

Thiazolylalanine, in appropriately functionalized form, has been found to function as an enantioselective catalyst for an intramolecular Stetter reaction. Incorporation of the residue in a number of environments has resulted in a family of catalysts that promote the cyclization of a test substrate with up to 81% enantiomeric excess.

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