Convenient magnesiation of aromatic and heterocyclic rings bearing a hydroxy group in presence of LiCl

Literature Information

Publication Date 2004-08-26
DOI 10.1039/B409664A
Impact Factor 6.222
Authors

Felix Kopp, Arkady Krasovskiy, Paul Knochel


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Abstract

The reaction of various iodophenols with MeMgCl in presence of LiCl followed by the addition of i-PrMgCl provides the corresponding magnesiated magnesium phenolates as THF soluble reagents; this approach can be extended to heterocyclic compounds bearing a hydroxy group like pyridines and quinolines.

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