Use of inherently conducting polymers and pulsed amperometry in flow injection analysis to detect oligonucleotides
Literature Information
Publication Date
2004-06-07
DOI
10.1039/B403136A
Impact Factor
4.616
Authors
Yanzhe Wu, Simon E. Moulton, Chee O. Too, Gordon G. Wallace, Dezhi Zhou
View Original
Abstract
Pulsed amperometry has been used to detect and discriminate between different base-pair oligonucleotides using flow injection analysis with polypyrrole modified electrodes. Oligonucleotides with 20-repeat units were immobilized as the sole counter anion during polymerisation of pyrrole onto a glassy carbon (GC) electrode. The modified electrode was then used in a flow injection analysis (FIA) set-up to selectively detect complementary oligonucleotides. Results showed that complementary oligo(dG)20 and non-complementary oligonucleotides can be distinguished by using the oligo(dC)20 modified electrode.
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Source Journal
Analyst
CiteScore:
7.8
Self-citation Rate:
5.6%
Articles per Year:
653
Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
Recommended Compounds
(1H-Benzotriazol-1-yloxy)(di-1-pyrrolidinyl)methylium hexafluorophosphate
CAS Number:
105379-24-6
Molecular Formula:
C15H21F6N5OP
![[4-Amino-2-(methylsulfanyl)-5-pyrimidinyl]methanol structure](https://static.chemtradehub.com/structs/588/588-36-3-fc73.webp "[4-Amino-2-(methylsulfanyl)-5-pyrimidinyl]methanol structure")
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