Novel model peptide for Atx1-like metallochaperones

Literature Information

Publication Date 2004-02-06
DOI 10.1039/B315489K
Impact Factor 6.222
Authors

Olivier Sénèque, Serge Crouzy, Didier Boturyn, Pascal Dumy, Michel Ferrand, Pascale Delangle


View Original

Abstract

The novel cyclodecapeptide c(GMTCSGCSRP) is able to bind soft metals with a selectivity for Hg2+ and Cu+ over Pb2+, Cd2+ and Zn2+, and is demonstrated to be an excellent structural model of the binding loop of the copper metallochaperone Atx1 in its apo and mercury loaded forms.

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