Fast folding dynamics of an α-helical peptide with bulky side chains‡

Literature Information

Publication Date 2004-02-05
DOI 10.1039/B312348K
Impact Factor 3.676
Authors

Sarah A. Petty, Martin Volk


View Original

Abstract

The fast folding/unfolding dynamics of the α-helical polypeptide poly-N5-(3-hydroxypropyl)-L-glutamine, PHPG, was observed in D2O after a nanosecond laser-induced temperature jump of 1 °C. The sudden rise in temperature disturbs the helix–coil equilibrium of the peptide and the ensuing structural relaxation was monitored by time-resolved IR-spectroscopy of the amide I′ band with a time resolution of 12 ns. After an initial relaxation on the time scale of a few nanoseconds, probably arising from a local rearrangement of random coil or side chain structures, the helix–coil relaxation proceeds on the time scale of a few hundred nanoseconds. The observed time constant of 227 ns is very similar to the helix–coil relaxation time constants observed for short alanine-based peptides, in spite of the greater length and more complex and bulky side chain of PHPG.

Related Literature

Atomistic insights into the nanofluid transport through an ultra-confined capillary

Xiao Wang, Zhiliang Zhang, Jianying He

2018-01-12 Paper

DOI: 10.1039/C7CP08140E

Reactivity of hydropersulfides toward the hydroxyl radical unraveled: disulfide bond cleavage, hydrogen atom transfer, and proton-coupled electron transfer

Josep M. Anglada, Ramon Crehuet, Sarju Adhikari, Joseph S. Francisco

2018-01-17 Paper

DOI: 10.1039/C7CP07570G

Understanding water interactions with organic surfaces: environmental molecular beam and molecular dynamics studies of the water–butanol system

Sofia M. Johansson, Xiangrui Kong, Erik S. Thomson, Stéphane Briquez, Céline Toubin, Jan B. C. Pettersson

2018-12-20 Paper

DOI: 10.1039/C8CP04151B

X-ray absorption near edge structure and first-principles spectral investigations of cationic disorder in MgAl2O4 induced by swift heavy ions

S. Yoshioka, K. Tsuruta, T. Yamamoto, K. Yasuda, S. Matsumura, N. Ishikawa, E. Kobayashi

2018-02-01 Paper

DOI: 10.1039/C7CP07591J

Bridging solution properties to gas hydrate nucleation through guest dynamics

Peter G. Kusalik

2018-09-24 Communication

DOI: 10.1039/C8CP04466J

Preventing iron(ii) precipitation in aqueous systems using polyacrylic acid: some molecular insights

Pierre-Arnaud Artola, Bernard Rousseau, Carine Clavaguéra, Marion Roy, Dominique You, Gabriel Plancque

2018-06-06 Paper

DOI: 10.1039/C7CP02743E

Activated barrier crossing dynamics of a Janus particle carrying cargo

Tanwi Debnath, Pulak Kumar Ghosh

2018-09-07 Paper

DOI: 10.1039/C8CP04419H

Effect of chemical structure on the subglass relaxation dynamics of biobased polyesters as revealed by dielectric spectroscopy: 2,5-furandicarboxylic acid vs. trans-1,4-cyclohexanedicarboxylic acid

L. Genovese, M. Soccio, N. Lotti, A. Munari, A. Szymczyk, S. Paszkiewicz, A. Linares, A. Nogales, T. A. Ezquerra

2018-05-23 Paper

DOI: 10.1039/C8CP01810C

Mixed-dimensional 2D/3D heterojunctions between MoS2 and Si(100)

Hyunsoo Choi, Kyung-Ah Min, Janghwan Cha, Suklyun Hong

2018-10-01 Paper

DOI: 10.1039/C8CP05201H

Intermolecular interactions upon carbon dioxide capture in deep-eutectic solvents

Shashi Kant Shukla

2018-09-10 Paper

DOI: 10.1039/C8CP03724H

You might also like

155412-88-71-(3-Aminophenyl)-3-...
Compound Q&A

How should waste containing 1-(D-Ribofuranosyl)-1,4-dihydro-3-pyridinecarboxamide (CAS: 19132-12-8) be handled?

Waste containing 1-(D-Ribofuranosyl)-1,4-dihydro-3-pyridinecarboxamide (CAS: 191...

19132-12-81-(D-Ribofuranosyl)-...
Compound Q&A

What regulatory guidelines apply to 2-Methyl-2-propanyl 3-bromo-3-(hydroxymethyl)-1-azetidinecarboxylate (CAS: 2007919-81-3)?

2-Methyl-2-propanyl 3-bromo-3-(hydroxymethyl)-1-azetidinecarboxylate (CAS: 20079...

2007919-81-32-Methyl-2-propanyl ...
Compound Q&A

What is N-(4-Chloro-2-pyridinyl)acetamide (CAS: 245056-66-0)?

N-(4-Chloro-2-pyridinyl)acetamide (CAS: 245056-66-0) is a chemical compound with...

245056-66-0N-(4-Chloro-2-pyridi...
Compound Q&A

What is 5-Chloro-2-hydroxybenzoic acid (CAS: 321-14-2)?

5-Chloro-2-hydroxybenzoic acid, also known as 5-chlorosalicylic acid, is an arom...

321-14-25-Chloro-2-hydroxybe...
Compound Q&A

What precautions should be taken when handling 1,1-Dichloro-1-fluoroethane (CAS: 1717-00-6)?

When handling 1,1-Dichloro-1-fluoroethane (CAS: 1717-00-6), it is important to u...

1717-00-61,1-Dichloro-1-fluor...
Compound Q&A

What are the physical and chemical properties of Fmoc-(2S,3R)-3-phenylpyrrolidine-2-carboxylic acid (CAS: 281655-32-1)?

Fmoc-(2S,3R)-3-phenylpyrrolidine-2-carboxylic acid is a white crystalline solid ...

281655-32-1Fmoc-(2S,3R)-3-pheny...
Compound Q&A

What are the main uses of 4-Amino-5-bromo-2-pyridinecarboxylic acid (CAS: 1363381-01-4)?

4-Amino-5-bromo-2-pyridinecarboxylic acid is primarily used as a precursor in th...

1363381-01-44-Amino-5-bromo-2-py...
1007881-98-2(S)-tert-butyl 2-((2...
Compound Q&A

What precautions should be taken when handling 8-bromo-2,2-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-3-one (CAS: 688363-73-7)?

When handling 8-bromo-2,2-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-3-one, use prop...

688363-73-78-bromo-2,2-dimethyl...

Source Journal

Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
CiteScore: 5.5
Self-citation Rate: 10.3%
Articles per Year: 3036

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.

Recommended Compounds

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.