Overoxidation of carbon-fiber microelectrodes enhances dopamine adsorption and increases sensitivity
Literature Information
Publication Date
2003-11-11
DOI
10.1039/B307024G
Impact Factor
4.616
Authors
Michael L. A. V. Heien, Paul E. M. Phillips, Garret D. Stuber, Andrew T. Seipel, R. Mark Wightman
View Original
Abstract
The voltammetric responses of carbon-fiber microelectrodes with a 1.0 V and a 1.4 V anodic limit were compared in this study. Fast-scan cyclic voltammetry was used to characterize the response to dopamine and several other neurochemicals. An increase in the adsorption properties of the carbon fiber leads to an increase in sensitivity of 9 fold in vivo. However the temporal response of the sensor is slower with the more positive anodic limit. Increased electron transfer kinetics also causes a decrease in the relative sensitivity for dopamine vs. other neurochemicals, and a change in their cyclic voltammograms. Stimulated release in the caudate-putamen was pharmacologically characterized in vivo using Ro-04-1284 and pargyline, and was consistent with that expected for dopamine.
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Source Journal
Analyst
CiteScore:
7.8
Self-citation Rate:
5.6%
Articles per Year:
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Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
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CAS Number:
120928-09-8
Molecular Formula:
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