Stereoselective synthesis of individual isomers of Leu-enkephalin analogues containing substituted β-turn bicyclic dipeptide mimetics
Literature Information
Chiyi Xiong, Junyi Zhang, Peg Davis, Jinfa Ying, Frank Porreca, Victor J. Hruby
Novel constrained β-turn dipeptide mimetics, 8-phenyl thiaindolizidinone amino acids 3, have been synthesized stereoselectively and incorporated into Leu-enkephalin peptides as a replacement of dipeptide Gly–Phe to afford four individual isomers of Leu-enkephalin analogues 6.
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