Zn-Proline catalyzed direct aldol reaction in aqueous media
Literature Information
Tamis Darbre, Miguel Machuqueiro
Zn complexes of proline, lysine and arginine are efficient catalysts for the aldol addition of p-nitrobenzaldehyde and acetone in aqueous medium, giving quantitative yields and enantiomeric excesses up to 56% with 5 mol% of the catalysts at room temperature.
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