Synthesis and reactions of a novel 3,4-didehydropyroglutamate derivative
Literature Information
Makoto Oba, Naohiro Nishiyama, Kozaburo Nishiyama
Some reactions such as catalytic hydrogenation, Diels–Alder reaction, cyclopropanation, dihydroxylation, and Michael addition of a novel 3,4-didehydropyroglutamate derivative, in which the carboxylic group is protected as an ABO ester, are examined and found to take place in a stereospecific manner giving 3- and/or 4-substituted pyroglutamate derivatives without loss of enantiomeric purity at the α-position.
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![4,4-Difluoro-2-methyl-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline structure 4,4-Difluoro-2-methyl-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline structure](https://static.chemtradehub.com/structs/119/1194032-23-9-f426.webp)

![7-Bromo-5-chloro-1H-pyrazolo[4,3-b]pyridine structure 7-Bromo-5-chloro-1H-pyrazolo[4,3-b]pyridine structure](https://static.chemtradehub.com/structs/135/1351813-70-1-a716.webp)
