Synthesis and reactions of a novel 3,4-didehydropyroglutamate derivative
Literature Information
Makoto Oba, Naohiro Nishiyama, Kozaburo Nishiyama
Some reactions such as catalytic hydrogenation, Diels–Alder reaction, cyclopropanation, dihydroxylation, and Michael addition of a novel 3,4-didehydropyroglutamate derivative, in which the carboxylic group is protected as an ABO ester, are examined and found to take place in a stereospecific manner giving 3- and/or 4-substituted pyroglutamate derivatives without loss of enantiomeric purity at the α-position.
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