Synthesis and evaluation of photo-activatable β-diarylsydnone-l-alanines for fluorogenic photo-click cyclization of peptides
Literature Information
Zhuojun Yao, Xueting Wu, Xiaocui Zhang, Qin Xiong, Shichao Jiang, Zhipeng Yu
Herein, we design and synthesize a series of photoactivatable β-diarylsydnone-L-alanines (DASAs), which have excellent photo-reactivity with high fluorescence turn-on toward alkenes in a biocompatible environment. The environmental sensing properties of the resulting fluorescent pyrazoline-alanine facilitate its probing capability. By introducing the DASA residue on the side chain of linear peptides, the macrocyclic peptides resulting from the in situ photo-cyclization toward the alkene residue exhibited fluorogenic translocation through live cell membranes.
Related Literature
Benzotrithiophene and benzodithiophene-based polymers for efficient polymer solar cells with high open-circuit voltage
Guobing Zhang, Jianyu Yuan, Jingxuan Ma, Hongbo Lu, Longzhen Qiu, Wanli Ma
DOI: 10.1039/C3PY00251A
Fluorinated thienyl-quinoxaline-based D–π–A-type copolymer toward efficient polymer solar cells: synthesis, characterization, and photovoltaic properties
Chung-Hao Liu, Yen-Hao Hsu, Yun-Chen Chien, Chih-Yang Cheng
DOI: 10.1039/C3PY00235G
Thiophene based hyperbranched polymers with tunable branching using direct arylation methods
Forrest E. Michael
DOI: 10.1039/C3PY00412K
UV- and NIR-responsive polymeric nanomedicines for on-demand drug delivery
Gang Liu, Wei Liu, Chang-Ming Dong
DOI: 10.1039/C3PY21121E
Effects of “mature micelle” formation of Pluronic P123 on equilibrium between lactone and carboxylate forms of 10-hydrocamptothecin in water
Tianyuan Ci, Ting Li, Liang Chen, Guangtao Chang
DOI: 10.1039/C3PY00118K
SET-LRP synthesis of novel polyallene-based well-defined amphiphilic graft copolymers in acetone
Guolin Lu, Yongjun Li, Hao Guo, Weiyuan Du, Xiaoyu Huang
DOI: 10.1039/C3PY00145H
Synthesis and characterization of fluorinated polyionomers. Part I: polyperfluoro-sulfonylethoxy propylene vinyl ether sulfonimides containing aryl sulfonic acids
Anna M. Flach, Frederick E. Johnson, Israel Cabasso
DOI: 10.1039/C3PY00315A
A continuous-flow approach for the multi-gram scale synthesis of C2-alkyl- or β-amino functionalized 1,3-dicarbonyl derivatives and ondansetron drug using 1,3-dicarbonyls
Nirmala Mohanta, Krishna Nair, Dasharath Vishambar Sutar, Boopathy Gnanaprakasam
DOI: 10.1039/D0RE00171F
A controlled and versatile NCA polymerization method for the synthesis of polypeptides‡
Inmaculada Conejos-Sánchez, Aroa Duro-Castano, Alexander Birke, Matthias Barz, María J. Vicent
DOI: 10.1039/C3PY00347G
Synthesis of well-defined poly(2-(dimethylamino)ethyl methacrylate) under mild conditions and its co-polymers with cholesterol and PEG using Fe(0)/Cu(ii) based SARA ATRP
Rosemeyre A. Cordeiro, Nuno Rocha, Joana P. Mendes, Krzysztof Matyjaszewski, Tamaz Guliashvili, Arménio C. Serra, Jorge F. J. Coelho
DOI: 10.1039/C3PY00190C
You might also like
What is 1-(2,4,6-Trifluorophenyl)ethanol (CAS: 1250113-83-7)?
1-(2,4,6-Trifluorophenyl)ethanol is an organic compound with the CAS number 1250...
Is 1-(2,4-Dimethoxybenzyl)-4-(hydroxymethyl)-2-pyrrolidinone (CAS: 919111-34-5) safe?
1-(2,4-Dimethoxybenzyl)-4-(hydroxymethyl)-2-pyrrolidinone (CAS: 919111-34-5) is ...
What are the physical and chemical properties of (7S,15R)-6β,15-Diacetoxy-7α,20-epoxy-7-hydroxykaura-2,16-dien-1-one (CAS: 51419-51-3)?
(7S,15R)-6β,15-Diacetoxy-7α,20-epoxy-7-hydroxykaura-2,16-dien-1-one is a crystal...
What regulatory guidelines apply to rac-ethyl (1r,4r)-4-hydroxycyclohexane-1-carboxylate, trans (CAS: 3618-04-0)?
The compound rac-ethyl (1r,4r)-4-hydroxycyclohexane-1-carboxylate, trans (CAS: 3...
What is the market or research trend for 2-(2,4-Difluorophenoxy)-3-nitropyridine (CAS: 175135-62-3)?
The market for 2-(2,4-Difluorophenoxy)-3-nitropyridine (CAS: 175135-62-3) is cur...
What are the main uses of 6-Diazo-5-oxo-L-norleucine (CAS: 157-03-9)?
The main uses of 6-Diazo-5-oxo-L-norleucine (CAS: 157-03-9) include research in ...
What precautions should be taken when handling 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) (CAS: 173308-19-5)?
When handling 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) (CAS: 173308-19-5), i...
How is 5-Methylimidazo[1,2-a]pyridine-3-carbaldehyde (CAS: 178488-37-4) typically synthesized?
5-Methylimidazo[1,2-a]pyridine-3-carbaldehyde (CAS: 178488-37-4) can be synthesi...
Are there alternatives to 2,4,6-Trihydroxyisophthalaldehyde (CAS: 4396-13-8) in synthesis?
There are alternative reagents that can be used in the synthesis of 2,4,6-Trihyd...
What is (2Z)-3-(5-Fluoro-1H-indol-3-yl)-2-sulfanylacrylic acid (CAS: 179461-52-0)?
(2Z)-3-(5-Fluoro-1H-indol-3-yl)-2-sulfanylacrylic acid is a chemical compound wi...
Source Journal
Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.













