Novel intermolecular carbon radical addition to a nitrone: asymmetric synthesis of α-amino acids

Literature Information

Publication Date 2003-01-14
DOI 10.1039/B211570K
Impact Factor 6.222
Authors

Masafumi Ueda, Hideto Miyabe, Masako Teramachi, Okiko Miyata, Takeaki Naito


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Abstract

A nitrone was used as a synthetically useful radical acceptor in carbon–carbon bond-forming radical reactions; the intermolecular addition of alkyl radicals to chiral glyoxylic nitrone was studied; a high degree of stereocontrol in radical addition to glyoxylic nitrone was achieved to provide a new method for asymmetric synthesis of α-amino acids.

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