A convenient stereoselective synthesis of trifluoromethyl-substituted polyfunctionalized cyclopropane: synthesis of (±)-trans-trifluoronorcoronamic acid

Literature Information

Publication Date 2003-01-29
DOI 10.1039/B210642F
Impact Factor 6.222
Authors

Biao Jiang, Fangjiang Zhang, Wennan Xiong


View Original

Abstract

Trifluoromethylated polyfunctionalized cyclopropanes were obtained in high stereoselectivity by reacting 2-bromo-3,3,3-trifluoropropene (BrTFP) with active methylenes. This novel method was further applied to the synthesis of (±)-trans-trifluoronorcoronamic acid.

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