Synthesis, biological evaluation and DNA binding properties of novel mono and bisnaphthalimides

Literature Information

Publication Date 2003-01-24
DOI 10.1039/B209042B
Impact Factor 3.876
Authors

Miguel F. Braña, Mónica Cacho, Ana Ramos, M. Teresa Domínguez, Jose M. Pozuelo, Cristina Abradelo, M. Fernanda Rey-Stolle, Mercedes Yuste, Carolina Carrasco, Christian Bailly


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Abstract

A novel series of mono and bisnaphthalimides was synthesized and their antiproliferative activities were evaluated against three tumor cell lines. Bisnaphthalimides 3 and 4, bearing a pyrazine ring fused to the naphthalimide system, showed activities in the order of 10−8 µM, similar to elinafide. DNA binding properties and the ability to induce DNA damage were studied for some of the most active compounds.

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Inside front cover

Front/Back Matter

DOI: 10.1039/B717329F

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Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry
CiteScore: 3.4
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Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

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