New fluorescent probes for visual proteins Part I. Photophysical properties of 3-(oxo)propenyl-4′-(N,N-dimethylamino)benzoate
Literature Information
Vladislav Papper, Vladimir Kharlanov, Wolfgang Rettig
Dual fluorescent compounds, derivatives of DMABN, are described which bear a spacer and an aldehyde group enabling their use as fluorescent probes in proteins containing amino functions. They are designed to be incorporated into the chromophore-binding pocket of the visual pigment rhodopsin or of the bacterial proton pump bacteriorhodopsin. The present study describes the synthesis and photophysical properties. The dual fluorescence observed is similar to that of the compound without attachment linker but the presence of several conformers and isomers brings in complications such as excitation wavelength dependence, spectral red shifts and low fluorescence quantum yields.
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Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.












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![6-Bromo-3-ethyl-3H-imidazo[4,5-b]pyridine structure 6-Bromo-3-ethyl-3H-imidazo[4,5-b]pyridine structure](https://static.chemtradehub.com/structs/103/1033202-59-3-2a8f.webp)