Pilocarpine | CAS No. 92-13-7

Pilocarpine

Basic Information

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CAS Number

92-13-7

Molecular Formula

C11H16N2O2

Molecular Weight

208.26 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

34°

Boiling Point

bp5 260° (partial conversion to isopilocarpine)

Density

1.1123 (rough estimate)

Refractive Index

1.5000 (estimate)

Specific Rotation

D18 +106° (c = 2)

SMILES

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CCC1C(COC1=O)CC2=CN=CN2C

InChI

InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1

InChIKey

QCHFTSOMWOSFHM-WPRPVWTQSA-N

LogP

1.1618

pKa

6.87(at 30℃)

Topological Polar Surface Area

44.120000000000005 Å²

Hydrogen Bond Donor/Acceptor

0 / 4

Complexity

245

Safety Information

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Hazard Statement

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

(3S,4R)-3-Ethyl-4-((1-methyl-1H-imidazol-5-yl)methyl)dihydrofuran-2(3H)-one
Pilocarpine
Pilocarpin Hcl
PILOCARPINE(RG)
actone
Ocucarpine
Ocusert
ocusertp20
Pilocarpin
Pilocarpol
Pilokarpin
pilokarpol
Syncarpine
Salagen
(+)-Pilocarpine
Isoptocarpine
Ocusert pilo
Ocusert P 20
Pilocarpine chloride
(3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one
Pilocarpine monohydrochloride
01MI4Q9DI3
QCHFTSOMWOSFHM-WPRPVWTQSA-N
(3S-cis)-3-Et
(3S,4R)-3-Ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone (ACI)
2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, (3S-cis)- (ZCI)
Pilocarpine (8CI)
MeSH ID: D010862
Ocusert Pilo
Ocusert Pilo 40
Pilocarpine, (+)-

MDL Number

MFCD00153042

FAQ

What are the physical and chemical properties of Pilocarpine (CAS: 92-13-7)?

Pilocarpine (CAS: 92-13-7) is a white to off-white crystalline powder. It has a molecular weight of 247.27 g/mol and a solubility of 2.54 g/mL in water. Pilocarpine is moderately reactive with basic substances and stable under normal storage conditions. It exhibits low volatility and is not flammable.

How is Pilocarpine (CAS: 92-13-7) typically synthesized?

Pilocarpine (CAS: 92-13-7) is typically synthesized via an aromatic amination process. The primary route involves the amination of 1-(2-hydroxyethyl)-3,4-dihydroxybenzene, followed by conversion to the desired amine. Common catalysts include ammonium acetate or other basic catalysts, and the overall process yields a high purity product with good selectivity.

What industries use Pilocarpine (CAS: 92-13-7)?

Pilocarpine (CAS: 92-13-7) is primarily used in the pharmaceutical industry for the treatment of glaucoma and dry eye syndrome. It is also utilized in research for studying muscarinic receptors and ion channels. Some applications in the sensor industry include its use in biosensors for monitoring sweat chloride levels in cystic fibrosis diagnostics.

What precautions should be taken when handling Pilocarpine (CAS: 92-13-7)?

When handling Pilocarpine (CAS: 92-13-7), safety precautions include the use of personal protective equipment (PPE) such as gloves, goggles, and lab coats. It should be handled in a well-ventilated area or fume hood. Spills should be cleaned up immediately with appropriate absorbent materials, and contaminated items should be disposed of according to local regulations. Consult the safety data sheet (SDS) for detailed emergency procedures and storage requirements.