3-methyl-1H-indazol-5-amine

Basic Information

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CAS Number

90764-90-2

Molecular Formula

C8H9N3

Molecular Weight

147.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

209.7°C at 760 mmHg

Density

1.295

Flash Point

102.7°C

Refractive Index

1.736

SMILES

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CC1=C2C=C(C=CC2=NN1)N

InChI

InChI=1S/C8H9N3/c1-5-7-4-6(9)2-3-8(7)11-10-5/h2-4H,9H2,1H3,(H,10,11)

InChIKey

HQMYDRGGBUKAKP-UHFFFAOYSA-N

LogP

1.45352

Topological Polar Surface Area

54.7 Å²

Hydrogen Bond Donor/Acceptor

3 / 3

Complexity

148

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

5-Amino-3-methyl-1H-indazole
3-methyl-1H-indazol-5-amine
3-methyl-2H-indazol-5-amine
5-Amino-3-methylindazole
1H-Indazole, 5-amino-3-methyl- (6CI, 7CI)
3-Methyl-1H-indazol-5-amine (ACI)
(3-Methyl-1H-indazol-5-yl)amine
3-Methyl-2H-indazol-5-amine
CS-W009222
5-amino-3-methyl indazole
DB-032290
Z825783034
AKOS006238567
SCHEMBL266855
AC-27139
5-AMINO-3-METHYLINDAZOLE
3-Methyl-1H-indazol-5-ylamine
DTXSID90461525
EN300-55150
3-Methyl-1H-indazol-5-amine, AldrichCPR
1H-INDAZOL-5-AMINE, 3-METHYL-
GS-3913
MFCD08272110
PB32584
SY096908
90764-90-2
J-512815

MDL Number

MFCD08272110

FAQ

What are the physical and chemical properties of 3-methyl-1H-indazol-5-amine (CAS: 90764-90-2)?

3-methyl-1H-indazol-5-amine has a crystalline form and a molecular weight of approximately 168.22 g/mol. It is sparingly soluble in water but soluble in organic solvents like ethanol and methanol. Chemically, it is mildly basic and can undergo nucleophilic substitution reactions under certain conditions. The compound is stable under normal laboratory conditions but should be stored in a cool, dry place away from direct sunlight.

How is 3-methyl-1H-indazol-5-amine (CAS: 90764-90-2) typically synthesized?

3-methyl-1H-indazol-5-amine can be synthesized through a multistep process involving the condensation of methyl isocyanide with 1H-indazole. The reaction is typically catalyzed by a Lewis acid such as aluminum chloride to achieve high yield and selectivity. The product is then purified by recrystallization and suitable solvents.

What industries use 3-methyl-1H-indazol-5-amine (CAS: 90764-90-2)?

3-methyl-1H-indazol-5-amine is primarily used in the pharmaceutical industry for its potential as an intermediate in the synthesis of various drugs. It also finds applications in the polymer industry for improving the properties of certain polymers and in the development of organic sensors for detecting specific chemicals.

What precautions should be taken when handling 3-methyl-1H-indazol-5-amine (CAS: 90764-90-2)?

When handling 3-methyl-1H-indazol-5-amine, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be used in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.