3-methyl-1H-indazol-5-amine(CAS: 90764-90-2)

3-methyl-1H-indazol-5-amine has a crystalline form and a molecular weight of approximately 168.22 g/mol. It is sparingly soluble in water but soluble in organic solvents like ethanol and methanol. Chemically, it is mildly basic and can undergo nucleophilic substitution reactions under certain conditions. The compound is stable under normal laboratory conditions but should be stored in a cool, dry place away from direct sunlight.

3-methyl-1H-indazol-5-amine can be synthesized through a multistep process involving the condensation of methyl isocyanide with 1H-indazole. The reaction is typically catalyzed by a Lewis acid such as aluminum chloride to achieve high yield and selectivity. The product is then purified by recrystallization and suitable solvents.

3-methyl-1H-indazol-5-amine is primarily used in the pharmaceutical industry for its potential as an intermediate in the synthesis of various drugs. It also finds applications in the polymer industry for improving the properties of certain polymers and in the development of organic sensors for detecting specific chemicals.

When handling 3-methyl-1H-indazol-5-amine, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be used in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.