(4R)-4-Hydroxy-D-proline hydrochloride (1:1)

Basic Information

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CAS Number

77449-94-6

Molecular Formula

C5H10ClNO3

Molecular Weight

167.59 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

114-126°C

Boiling Point

368.6℃ at 760 mmHg

Flash Point

368.6 °C at 760 mmHg

Specific Rotation

+16.5°-+19.8° (c=1, MeOH)

SMILES

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C1C(CNC1C(=O)O)O.Cl

InChI

InChI=1S/C5H9NO3.ClH/c7-3-1-4(5(8)9)6-2-3;/h3-4,6-7H,1-2H2,(H,8,9);1H/t3-,4-;/m1./s1

InChIKey

YEJFFQAGTXBSTI-VKKIDBQXSA-N

LogP

-0.7844000000000002

Topological Polar Surface Area

69.56 Å²

Hydrogen Bond Donor/Acceptor

3 / 4

Complexity

125

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

MFCD09749867
J-500995
(2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid HCl
EN300-131411
D-PROLINE, 4-HYDROXY-, HYDROCHLORIDE, (4R)-
(2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid hydrochloride
AKOS000278429
SCHEMBL2257034
(2R,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid hydrochloride
DTXSID00487236
Z1198181174
cis-4-Hydroxy-D-proline (hydrochloride)
rel-(2R,4R)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride
A24032
DS-0995
Cis-4-Hydroxy-D Proline hydrochloride
CIS-4-HYDROXY-D-PROLINE HCL
cis-4-Hydroxy-D-proline hydrochloride
CS-M0679
YEJFFQAGTXBSTI-VKKIDBQXSA-N
HY-76104
AC-4323
AM20100769
77449-94-6
(2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid;hydrochloride
Cis-4-Hydroxy-D-proline, HCl
Cis-4-Hydroxy-D-proline hydrochloride
cis-4-Hydroxy-D-proline hydrochloride ((2R,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid hydrochloride)
cis-4-Hydro×y-D-proline hydrochloride
(2R,4R)-4-hydroxyproline hydrochloride
(4-(2-chlorophenyl)thiazol-2-yl)Methanol

MDL Number

MFCD09749867

Customs Code

2933990090

FAQ

What are the physical and chemical properties of (4R)-4-Hydroxy-D-proline hydrochloride (CAS: 77449-94-6)?

(4R)-4-Hydroxy-D-proline hydrochloride is a white to off-white crystalline powder. It has a molecular weight of approximately 223.7 g/mol. This compound is soluble in water and slightly soluble in ethanol. It is used as a prodrug and in medicinal chemistry due to its reactivity and specific stereochemistry.

How is (4R)-4-Hydroxy-D-proline hydrochloride (CAS: 77449-94-6) typically synthesized?

(4R)-4-Hydroxy-D-proline hydrochloride can be synthesized through the hydrochloric acid treatment of (4R)-4-hydroxy-D-proline. This reaction typically involves the addition of hydrochloric acid to the proline derivative, leading to the formation of the hydrochloride salt. The process is known for its high yield and good selectivity.

What industries use (4R)-4-Hydroxy-D-proline hydrochloride (CAS: 77449-94-6)?

(4R)-4-Hydroxy-D-proline hydrochloride finds applications in the pharmaceutical industry, particularly in the development of prodrugs and medicinal chemistry. It is also used in the food and beverage industry for stabilizing and preserving certain properties of proteins and enzymes.

What precautions should be taken when handling (4R)-4-Hydroxy-D-proline hydrochloride (CAS: 77449-94-6)?

When handling (4R)-4-Hydroxy-D-proline hydrochloride, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or with a fume hood. Spills should be cleaned up using appropriate methods, and the material safety data sheet (MSDS) should be consulted for detailed handling instructions.