(4R)-4-Hydroxy-D-proline hydrochloride (1:1)(CAS: 77449-94-6)

(4R)-4-Hydroxy-D-proline hydrochloride is a white to off-white crystalline powder. It has a molecular weight of approximately 223.7 g/mol. This compound is soluble in water and slightly soluble in ethanol. It is used as a prodrug and in medicinal chemistry due to its reactivity and specific stereochemistry.

(4R)-4-Hydroxy-D-proline hydrochloride can be synthesized through the hydrochloric acid treatment of (4R)-4-hydroxy-D-proline. This reaction typically involves the addition of hydrochloric acid to the proline derivative, leading to the formation of the hydrochloride salt. The process is known for its high yield and good selectivity.

(4R)-4-Hydroxy-D-proline hydrochloride finds applications in the pharmaceutical industry, particularly in the development of prodrugs and medicinal chemistry. It is also used in the food and beverage industry for stabilizing and preserving certain properties of proteins and enzymes.

When handling (4R)-4-Hydroxy-D-proline hydrochloride, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or with a fume hood. Spills should be cleaned up using appropriate methods, and the material safety data sheet (MSDS) should be consulted for detailed handling instructions.