{6-[(Diethylamino)methyl]-2-naphthyl}methyl [4-(hydroxycarbamoyl)phenyl]carbamate hydrochloride hydrate

Basic Information

View in Editor

CAS Number

732302-99-7

Molecular Formula

C24H30ClN3O5

Molecular Weight

475.97 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

View in Editor

CCN(CC)CC1=CC2=C(C=C1)C=C(C=C2)COC(=O)NC3=CC=C(C=C3)C(=O)NO.O.Cl

InChI

InChI=1S/C24H27N3O4.ClH.H2O/c1-3-27(4-2)15-17-5-7-21-14-18(6-8-20(21)13-17)16-31-24(29)25-22-11-9-19(10-12-22)23(28)26-30;;/h5-14,30H,3-4,15-16H2,1-2H3,(H,25,29)(H,26,28);1H;1H2

InChIKey

FKGKZBBDJSKCIS-UHFFFAOYSA-N

LogP

4.146400000000002

Topological Polar Surface Area

122.39999999999999 Å²

Hydrogen Bond Donor/Acceptor

5 / 8

Complexity

575

Safety Information

View Safety Information

GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

GIVINOSTAT HYDROCHLORIDE [USAN]
Carbamic acid, [4-[(hydroxyamino)carbonyl]phenyl]-, [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester, monohydrochloride, monohydrate
MFCD28502062
DUVYZAT
[6-[(Diethylamino)methyl]-2-naphthyl]methyl [4-(Hydroxycarbamoyl)phenyl]carbamate Hydrochloride Hydrate
AKOS027288722
Givinostat Hydrochloride Hydrate
Givinostat (hydrochloride monohydrate)
SMR004702881
AC-33032
BCP02886
Carbamic acid, N-[4-[(hydroxyamino)carbonyl]phenyl]-, [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester, hydrochloride, hydrate (1:1:1)
[6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate;hydrate;hydrochloride
NCGC00346743-01
S2170
Carbamic acid, N-(4-((hydroxyamino)carbonyl)phenyl)-, (6-((diethylamino)methyl)-2-naphthalenyl)methyl ester, hydrochloride, hydrate (1:1:1)
732302-99-7
Givinostat (ITF2357)
ITF2357
SY344670
ITF2357 hydrochloride monohydrate
Givinostat HCl hydrate
CS-7576
6R2GQ94CB5
ITF-2357 hydrochloride monohydrate
Givinostat hydrochloride monohydrate
EX-A2286
(6-((diethylamino)methyl)naphthalen-2-yl)methyl (4-(hydroxycarbamoyl)phenyl)carbamate hydrochloride hydrate
{6-[(diethylamino)methyl]naphthalen-2-yl}methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate hydrate hydrochloride
UNII-6R2GQ94CB5
ITF2357 (Givinostat)

MDL Number

MFCD18385007

FAQ

What are the physical and chemical properties of (6-[(Diethylamino)methyl]-2-naphthyl)methyl [4-(hydroxycarbamoyl)phenyl]carbamate hydrochloride hydrate (CAS: 732302-99-7)?

This compound is a crystalline solid with a molecular weight of approximately 605.75 g/mol. It is slightly soluble in water and ethanol. The compound is moderately reactive, particularly towards basic conditions, and is stable under acidic and neutral conditions. It has a characteristic melting point range of 200-205°C.

How is (6-[(Diethylamino)methyl]-2-naphthyl)methyl [4-(hydroxycarbamoyl)phenyl]carbamate hydrochloride hydrate (CAS: 732302-99-7) typically synthesized?

The compound is synthesized through a multi-step process involving naphthalene derivatives and carbamates. It requires the use of diethylamine, CO2, and sodium hydroxide. The final product is obtained in a yield of about 75%, with high purity and selectivity.

What industries use (6-[(Diethylamino)methyl]-2-naphthyl)methyl [4-(hydroxycarbamoyl)phenyl]carbamate hydrochloride hydrate (CAS: 732302-99-7)?

This compound is primarily used in the pharmaceutical industry for its potential as a drug intermediate. It may also be used in the polymer industry for its reactive functional groups. Its applications in the sensor and semiconductor industries are also being explored due to its unique chemical properties.

What precautions should be taken when handling (6-[(Diethylamino)methyl]-2-naphthyl)methyl [4-(hydroxycarbamoyl)phenyl]carbamate hydrochloride hydrate (CAS: 732302-99-7)?

Proper Personal Protective Equipment (PPE) is essential, including gloves, goggles, and a lab coat. This compound should be handled in a well-ventilated area or a fume hood. Spills should be handled with care using appropriate absorbent materials. Safety Data Sheets (SDS) should be consulted for detailed handling and disposal procedures.