2,4-Dichloro-6-methylpyrimidine

Basic Information

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CAS Number

5424-21-5

Molecular Formula

C5H4Cl2N2

Molecular Weight

163.01 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Solid

Melting Point

45.0 to 49.0 deg-C

Boiling Point

219°C

Water Solubility

Soluble in Chloroform, Ether, Ethyl Acetate and Toluene. Insoluble in water.

Refractive Index

1.6300 (estimate)

SMILES

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CC1=CC(=NC(=N1)Cl)Cl

InChI

InChI=1S/C5H4Cl2N2/c1-3-2-4(6)9-5(7)8-3/h2H,1H3

InChIKey

BTLKROSJMNFSQZ-UHFFFAOYSA-N

LogP

2.0918200000000002

Topological Polar Surface Area

25.78 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

Safety Information

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GHS Hazard Pictograms

H314

Hazard Statement

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class 8 Class 8

Synonyms & References

English

AM100927
Pyrimidine, 2,4-dichloro-6-methyl-
2,4-Dichloro-6-methylpyrimidine
W-105649
2,4-dichloro-6-methyl-pyrimidine
2,4-dichloro-6-methylpyrimidin
Z56761388
NSC 13199
2,4-Dichloro6-methylpyrimidine
CS-D1522
D2958
NS00033012
NSC13199
5424-21-5
FT-0610029
MFCD00006064
Pyrimidine,4-dichloro-6-methyl-
GS-6846
EN300-26901
2,4-dichloro-6-methyl pyrimidine
AC-26613
SB10363
DTXSID0063868
6-methyl-2,4-dichloropyrimidine
SCHEMBL104786
6N8JD43WQQ
A7890
AI3-26572
EINECS 226-563-4
NSC-13199
2,4-dichloro-6-methylprimidine

MDL Number

MFCD00006064

Customs Code

2933599090

FAQ

What are the physical and chemical properties of 2,4-Dichloro-6-methylpyrimidine (CAS: 5424-21-5)?

2,4-Dichloro-6-methylpyrimidine (CAS: 5424-21-5) is a white crystalline solid with a molecular weight of approximately 214.03 g/mol. It has a low solubility in water but is more soluble in organic solvents like methanol and ethanol. The compound exhibits moderate reactivity, particularly towards nucleophiles and reducing agents. It is stable under normal storage conditions but should be kept away from strong oxidizers and reductants.

How is 2,4-Dichloro-6-methylpyrimidine (CAS: 5424-21-5) typically synthesized?

2,4-Dichloro-6-methylpyrimidine (CAS: 5424-21-5) can be synthesized through the reaction of 6-methylpyrimidine with chlorine gas in the presence of a suitable catalyst such as iron chloride. The synthesis yields a mixture that can be purified by recrystallization or distillation. The process is selective and produces a high yield of the desired product.

What industries use 2,4-Dichloro-6-methylpyrimidine (CAS: 5424-21-5)?

2,4-Dichloro-6-methylpyrimidine (CAS: 5424-21-5) is primarily used in the pharmaceutical industry for the synthesis of certain drugs, particularly those requiring pyrimidine derivatives. It is also used in the polymer industry for the development of advanced materials and in semiconductor manufacturing for specific applications.

What precautions should be taken when handling 2,4-Dichloro-6-methylpyrimidine (CAS: 5424-21-5)?

When handling 2,4-Dichloro-6-methylpyrimidine (CAS: 5424-21-5), ensure proper personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize exposure. Follow standard laboratory safety guidelines for working with potentially reactive compounds. In case of spills, clean up with appropriate absorbent materials and dispose of waste according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.