2,2-Difluoroethanamine

Basic Information

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CAS Number

430-67-1

Molecular Formula

C2H5F2N

Molecular Weight

81.07 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Specialty Chemicals UV Stabilizers

Electronic Chemicals Semiconductor Materials Etchants

Water Treatment Chemicals Disinfectants Chlorine Compounds

Basic Physical Properties

Boiling Point

68°C

Flash Point

-33.5±10.2 ºC,

Refractive Index

1.3410-1.3450

SMILES

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C(C(F)F)N

InChI

InChI=1S/C2H5F2N/c3-2(4)1-5/h2H,1,5H2

InChIKey

OVRWUZYZECPJOB-UHFFFAOYSA-N

LogP

0.21019999999999994

Topological Polar Surface Area

26.02 Å²

Hydrogen Bond Donor/Acceptor

2 / 1

Complexity

21.6

Safety Information

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Hazard Statement

H225 Highly Flammable liquid and vapor
Flammable liquids

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class IRRITANT Class IRRITANT

Sensitiveness

Sensitive to air

Synonyms & References

English

2,2,-difluorethylamine
SY013766
2,2-difluoro-ethylamine
Ethylamine, 2,2-difluoro-
AKOS000312685
2,2-difluoroethane-1-amine
2,2-difluoroethanamine
Ethanamine, 2,2-difluoro-
2,2-bis(fluoranyl)ethanamine
2,2-difluoroethan-1-amine
D4758
EC 671-709-6
A826136
2,2-difluoroethyl amine
BB 0260215
CHEMBL1162281
EN300-115962
AMY7132
LR6CDA8ZPD
2,2-Difluoroethylamine
2,2-Difluoroethylamine, AldrichCPR
2,2-difluorethylamine
O10557
difluoroethylamine
CF2HCH2NH2
2,2-difluoro-ethanamine
2,2-di-fluoro-ethylamine
DTXSID40195621
NS00003724
MFCD00798137
430-67-1

MDL Number

MFCD00798137

Customs Code

2921199090

FAQ

What are the physical and chemical properties of 2,2-Difluoroethanamine (CAS: 430-67-1)?

2,2-Difluoroethanamine (CAS: 430-67-1) is a colorless, flammable liquid with a molecular weight of 107.04 g/mol. It has a slight amine odor and is miscible with water. The compound is slightly soluble in ethanol and ether. It is reactive towards strong acids and bases, and it can undergo nucleophilic substitution reactions. Under normal conditions, it is stable but should be stored away from strong oxidizers and heat sources.

How is 2,2-Difluoroethanamine (CAS: 430-67-1) typically synthesized?

2,2-Difluoroethanamine (CAS: 430-67-1) is commonly synthesized via the reaction of 2,2-difluoroethanol with ammonium hydroxide. This process takes place in the presence of a suitable catalyst, such as palladium on carbon, and proceeds with good selectivity. The yield is typically around 80-90%, depending on the reaction conditions and purification method.

What industries use 2,2-Difluoroethanamine (CAS: 430-67-1)?

2,2-Difluoroethanamine (CAS: 430-67-1) is primarily used in the pharmaceutical industry for the synthesis of various drugs, particularly those that require fluoroalkyl substituents. It is also used in the polymer industry for modifying the properties of polymers and in the semiconductor industry for etching processes. Additionally, it can be employed in the production of sensors and as a solvent in laboratory settings.

What precautions should be taken when handling 2,2-Difluoroethanamine (CAS: 430-67-1)?

When handling 2,2-Difluoroethanamine (CAS: 430-67-1), it is essential to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight and heat sources. It should be handled in a well-ventilated area or a fume hood. In case of a spill, it is recommended to use appropriate spill kits and follow the safety data sheet (SDS) for further guidance. Exposure to the compound can cause skin irritation and respiratory issues, so it is crucial to avoid inhalation and contact with the eyes or skin.